TAB3 Polyclonal Antibody - BT-AP14707

TAB3 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP14707-20, BT-AP14707-50, BT-AP14707-100

Citations, Manuals and MSDS Available upon request.

Background: The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Research Areas: Epigenetics and nuclear signaling; Signal transduction; Immunology

Target Protein: TAB3

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q8N5C8; Mouse: Q571K4

Synonyms: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3;Mitogen-activated protein kinase kinase kinase 7-interacting protein 3;NF-kappa-B-activating protein 1;TAK1-binding protein 3;TAB-3;TG

GeneID: Human: 257397

Research Use Only