Product Description

TAB3 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA35198-50, RA35198-100

Citations, Manuals and MSDS Available upon request.

Background: TGF-beta activated kinase 1/MAP3K7 binding protein 3 (TAB3) Homo sapiens The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008],

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000

Applications: WB; ELISA

Species Cross-Reactivity: Human; Mouse

GeneID (Human): 257397

Protein MW (KDa): 78

SWISS: Q8N5C8

Source: Rabbit

Research Use Only