Product Description

TACC3 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91314-50, BS91314-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9Y6A5(Human) Q9JJ11(Mouse) Unigene:58838(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC/IF, IHC

All Applications: WB:1:1,000-1:5,000
ICC:1:100-1:500
IHC:1:100-1:500

Background: TACC1 (transforming acidic coiled coil gene 1) is one of three TACC family members, which are thought to be involved in breast tumorigenesis. TACC1 is located on 8p11 chromosomal region that is amplified in approximately 15% of all breast tumor samples. The short arm of chromosome 8 also contains FGFR1 whose expression is enhanced in most breast cancer tumors. TACC family members, TACC1, TACC2, and TACC3, map very closely to the corresponding FGFR1, FGFR2, FGFR3 genes on chromosomes 8, 10, and 4. Subsequently, since they are phylogenetically related, it is proposed that TACC and FGFR have similar roles in cell growth and differentiation. Also, TACC1 contains a conserved C-terminal region as in the Drosophila homolog, D-TACC. It has been shown that D-TACC is necessary for normal spindle function, and the mammalian TACC proteins appears to interact with centrosomes and microtubules in a similar manner.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: TACC3 polyclonal antibody detects endogenous levels of TACC3 protein.

Bioworld Molecular Weight: 140 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of TACC3 on Hela cells lysates using anti-TACC3 antibody at 1/1,000 dilution., ICC staining TACC3 in PANC-1 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: TACC3, ERIC 1, ERIC-1, ERIC1, MGC117382, MGC133242, OTTHUMP00000113796, TACC3, TACC3, Transforming acidic coiled coil containing protein 3, Transforming acidic coiled-coil-containing protein 3,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified