Product Description

TADA2L Polyclonal Antibody

Catalogue Numbers: BS5953-50, BS5953-100

Sizes: 50µl, 100µl

Alternative Name: Transcriptional adapter 2-alpha; Transcriptional adapter 2-like; ADA2-like protein; TADA2A; TADA2L; KL04P

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O75478

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB ICC

All Applications: WB: 1:500~1:1000
ICC: 1:50~1:200

Background: TADA2L (transcriptional adapter 2-like), also known as TADA2A (transcriptional adapter 2-α) or ADA2-like protein, is a 443 amino acid nuclear protein that exists as 2 alternatively spliced isoforms. While most abundantly expressed in testis, TADA2L is present in all tissues. TADA2L contains one SANT domain and one SWIRM domain, and interacts with GCN5 and GR (NR3C1). Its ability to bind double-stranded DNA allows TADA2L to play a role in chromatin remodeling. Although it makes up part of the PCAF complex, TADA2L is also a component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. The gene that encodes TADA2L contains 71,408 bases and maps to human chromosome 17q12. Chromosome 7 houses over 1,000 genes, comprises nearly 5% of the human genome and has been linked to osteogenesis imperfecta, Pendred syndrome, lissencephaly, citrullinemia and Shwachman-Diamond syndrome.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TADA2L polyclonal antibody detects endogenous levels of TADA2L protein.

Bioworld Molecular Weight: ~ 51 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of TADA2L polyclonal antibody at 1:500 dilution
Lane 1: MCF-7 cell lysate
Lane 2: sp2/0 cell lysate
Lane 3: H9C2 cell lysate

Immunogen: Synthetic peptide, corresponding to amino acids 248-293 of Human TADA2L.

Conjugate: Unconjugated

Modification: Unmodified