Product Description

TAGLN2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS8419-50, BS8419-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P37802

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB IF

All Applications: WB: 1:500~1:2000
IF: 1:50~1:200

Background: Transgelin (also designated SM22α), is expressed abundantly in smooth muscle cells. Transgelin-2 (also known as SM22α homolog) is a homolog of transgelin and is also expressed in smooth muscle cells and by peritoneal B-1 cells. The human transgelin-2 gene (designated TAGLN2), which is located on chromosome 1q231-q25, encodes a 199 amino acid protein that contains a calponin-like repeat and a calponin-homology (CH) domain. Transgelin-2 may function very similarly to transgelin. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is downregulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds actin, causing actin fibers to gel within minutes of binding. Binding of transgelin to actin occurs at a ratio of 1:6 actin monomers.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TAGLN2 polyclonal antibody detects endogenous levels of TAGLN2 protein.

Bioworld Molecular Weight: ~ 22 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western Blot (WB) analysis of TAGLN2 polyclonal antibody

Alternative Name: Transgelin-2; Epididymis tissue protein Li 7e; SM22-alpha homolog; TAGLN2; KIAA0120; CDABP0035

Immunogen: Recombinant full length Human TAGLN2.

Conjugate: Unconjugated

Modification: Unmodified