Product Description

Tak1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: AP0460-50, AP0460-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

Swiss-Prot: O43318

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB,

All Applications: WB: 1:1000~1:2000

Background: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior. Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Tak1 polyclonal antibody detects endogenous levels of Tak1 protein.

Bioworld Molecular Weight: ~ 80 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of Tak1 polyclonal antibody at 1:1000 dilution
Lane 1: C6 whole cell lysate (30ug)
Lane 2: SP2/0 whole cell lysate (30ug)
Lane 3: A2780 whole cell lysate (30ug)
Lane 4: K562 whole cell lysate (30ug)

Alternative Name: Nuclear receptor subfamily 2 group C member 2; Orphan nuclear receptor TAK1; Orphan nuclear receptor TR4; Testicular receptor 4

Immunogen: Synthetic peptide, corresponding to Human Tak1 .

Conjugate: Unconjugated

Modification: Unmodified