Product Description

TAL-1 (Phospho-Ser122) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65228-50, BS65228-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: alternative products:The splicing pattern is cell-lineage dependent, disease:A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1, 14)(p32, q11) with T-cell receptor alpha chain (TCRA) genes., domain:The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1., function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regμlator of erythroid differentiation., PTM:Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimμlated by hypoxia., PTM:Ubiquitinated, subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascμlar endothelial cells, since it coμld not be observed in large vessel endothelial cells., similarity:Contains 1 basic helix-loop-helix (bHLH) domain., subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3., tissue specificity:Leukemic stem cell.,

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, ELISA

Alternate Names: TAL1, BHLHA17, SCL, TCL5, T-cell acute lymphocytic leukemia protein 1, TAL-1, Class A basic helix-loop-helix protein 17, bHLHa17, Stem cell protein, T-cell leukemia/lymphoma protein 5, TAL2, BHLHA19, T-cell acute lymphocytic leukemia protein 2, TAL-2, Class A basic helix-loop-helix protein 19, bHLHa19

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthesized acetyl-peptide derived from human TAL1/2 around the acetylation site of K221.

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity: Acetyl-TAL1/2 (K221/K222/K36/K37) Polyclonal Antibody detects endogenous levels of TAL1/2 around the acetylation site of K221 protein.

Molecular Weight: ~ 45 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P17542

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only