TAL1/2 (Acetyl Lys221/Acetyl Lys222/Acetyl Lys36/Acetyl Lys37) Polyclonal Antibody - BT-AP01689

TAL1/2 (Acetyl Lys221/Acetyl Lys222/Acetyl Lys36/Acetyl Lys37) Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP01689-20, BT-AP01689-50, BT-AP01689-100

Citations, Manuals and MSDS Available upon request.

Background: alternative products:The splicing pattern is cell-lineage dependent|disease:A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.|The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.|Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.|PTM:Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia.|PTM:Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122| ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells| since it could not be observed in large vessel endothelial cells.|Contains 1 basic helix-loop-helix (bHLH) domain.|subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3| LDB1| TAL1 and TCF3.|tissue specificity:Leukemic stem cell.|

Research Areas: Epigenetics and nuclear signaling; Developmental biology; Stem cells; Cancer; Cell biology

Target Protein: TAL1

Applications: WB, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: T-cell acute lymphocytic leukemia protein 1 homolog

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P17542; Mouse: P22091

Synonyms: T-cell acute lymphocytic leukemia protein 1 homolog/T-cell acute lymphocytic leukemia protein 2; TAL1; BHLHA17; SCL; TCL5; T-cell acute lymphocytic leukemia protein 1; TAL-1; Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5; TAL2; BHLHA19; T-cell acute lymphocytic leukemia protein 2; TAL-2; Class A basic helix-loop-helix protein 19; bHLHa19

GeneID: Human: 6886; Mouse: 21349

Research Use Only