Product Description

TAL1 (Acetyl-K221/K222) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS64094-50, BS64094-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Activation of TAL1 characterizes up to 60% ofcases of human T cell acute lymph oblastic leukemia, making it themost frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phospho protein and basic helixx-loop-helixtranscription factorknown to regμlate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box.In addition, leukemogenesisis accelerated dramatically bytransgenic coexpression of TAL1 and the catalyticsubunit ofcasein kinase IIα, a serine/threonine protein kinase known tomodμlate the activity of other βHLH transcription factors.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: T-cell acute lymphocytic leukemia protein 1, TAL-1, Class A basic helix-loop-helix protein 17, bHLHa17, Stem cell protein, T-cell leukemia/lymphoma protein 5, TAL1, T-cell acute lymphocytic leukemia protein 2, TAL-2, Class A basic helix-loop-helix protein 19, bHLHa19, TAL2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Acetylated

Immunogen: Synthetic Acetylated peptide derived from human TAL1 around the Acetylation site of K221/K222.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: TAL1 (Acetyl-K221/K222) polyclonal antibody detects endogenous levels of TAL1 protein only when acetylated at Lys221 and Lys222. This antibody also recognizes TAL2 protein when acetylated at Lys36 and Lys37.

Molecular Weight: ~ 34 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P17542/Q16559

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only