TAL1 rabbit pAb - ES7343

TAL1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES7343-50, ES7343-100

Citations, Manuals and MSDS Available upon request.

Background: alternative products:The splicing pattern is cell-lineage dependent, disease:A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t (1; 14) (p32; q11) with T-cell receptor alpha chain (TCRA) genes., domain:The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1., function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation., PTM:Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia., PTM:Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells., similarity:Contains 1 basic helix-loop-helix (bHLH) domain., subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3., tissue specificity:Leukemic stem cell.,

Alternate Name: TAL1; BHLHA17; SCL; TCL5; T-cell acute lymphocytic leukemia protein 1; TAL-1; Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human TAL-1. AA range:96-145

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 45kD

Human Gene ID: 6886

Human SWISS Prot NO: P17542

Subcellular Location: Nucleus

Research Use Only