Product Description

TANK (F194) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2231-50, BS2231-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The tumor necrosis factor (TNF) receptor superfamily is composed of several type I integral membrane glycoproteins that exhibit homology in their cystine- rich extracellμlar domains. Members of this family include TNF-RI and -RII, FAS, OX40, CD27, CD30 and CD40. Ligands for these receptors can be small, secreted proteins such as TNF, or type II integral membrane proteins, such as the CD40 ligand, CD40L. While the signal transduction mechanism of the TNF receptor superfamily is poorly understood, stimμlation of cells with either TNF or soluble CD40L has been shown to induce the nuclear translocation of NFκB. Members of the TRAF family associate with activated TNF-R and CD40 and have been implicated in this process. The discovery of a novel protein, designated TANK, has shed light on the means by which TRAF activation of NFkB occurs. TANK is not only capable of binding to all three TRAFs, but also of synergizing with TRAF2 to activate the NFκB signaling cascade. TANK contains a regμlatory carboxy terminal domain that maintains its inactivity in unstimμlated cells. Upon its association with TRAF2, the inhibitory effect of this domain is overcome.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF

Alternate Names: TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein, I-TRAF, TANK, ITRAF, TRAF2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 160-203 of Human TANK.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: TANK (F194) polyclonal antibody detects endogenous levels of TANK protein.

Molecular Weight: ~ 50 kDa

Pathway: NF-kB Signaling, STING Signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q92844

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only