Product Description

Tau (phospho-S396) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS4196-50, BS4196-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Tau, also known as MAPT (microtubμle-associated protein tau), MAPTL, MTBT1 or TAU, is a 758 amino acid protein that localizes to the cytoplasm, as well as to the cytoskeleton and the cell membrane, and contains four Tau/MAP repeats. Expressed in neuronal tissue and existing as mμltiple alternatively spliced isoforms, Tau functions to promote microtubμle assembly and stability and is thought to be involved in the maintenance of neuronal polarity. Tau may also link microtubμles with neural plasma membrane components and, addition to its role in microtubμle stability, is also necessary for cytoskeletal plasticity.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC

Alternate Names: Microtubμle-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPT, MAPTL, MTBT1, TAU

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Phosphorylation

Immunogen: Synthetic phosphopeptide derived from human isoforms Tau-4 around the phosphorylation site of Serine 396.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: p-Tau (S396) polyclonal antibody detects endogenous levels of Tau only when phosphorylated at Ser713, isoforms Tau-4 phosphorylated at Ser396, and other isoforms phosphorylated at the corresponding Site.

Molecular Weight: 50 to 80 kDa

Pathway: Neuronal and Glial Cell Marker Atlas, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P10636

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only