TAZ Polyclonal Antibody - E-AB-66586

TAZ Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-66586-60, E-AB-66586-120, E-AB-66586-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: TAZ

Target Synonym: BTK; AGMX1; AT; ATK; BPK; IMD1; PSCTK1; XLA; Bruton tyrosine kinase; TAZ; WWTR1

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Stem Cells

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse

Application: IF

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q9GZV5

Background: TAZ, also referred as WWTR1, is a transcriptional co-activator with a PDZ-binding motif that is regulated by its interaction with 14-3-3 protein. TAZ is expressed in many primary tumors, such as breast cancer, thyroid carcinoma, colorectal cancer, and glioma. TAZ has been reported to be one of the nuclear effectors of Hippo-related pathways that regulate organ size control, cancer stem cell (CSC) properties, and epithelial–mesenchymal transition (EMT). TAZ has been defined for its role in the nucleus, where it functions directly as a transcriptional regulator by interacting with several nuclear factors as Runx2/Cbfa1, NHERF-2, TEF-1, TBX5, PAX3, PAX8 and TTF-1.

Concentration: 1mg/mL

Immunogen: A synthetic peptide of human TAZ (NP_056287.1).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification Method: Affinity purification

Dilution: IF 1:50-1:200

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only