Product Description

TBC1D2 Polyclonal Antibody

Catalogue Numbers: BS60814-50, BS60814-100

Sizes: 50µl, 100µl

Alternative Name: TBC1 domain family member 2A; Armus; Prostate antigen recognized and identified by SEREX 1; PARIS-1; BC1D2; PARIS1; PP8997; TBC1D2A

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9BYX2

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in downregulation of their active form. TBC1D2 (TBC1 domain family member 2), also known as Armus or PARIS-1 (prostate antigen recognized and identified by SEREX 1), is a 928 amino acid protein containing a Rab-GAP TBC domain and a PH domain. Localizing to cytoplasm, cytoplasmic vesicles and cell junctions, TBC1D2 is expressed in a broad range of tissues, including kidney, liver, lung and placenta, as well as in keratinocytes and epithelia-containing organs. TBC1D2 functions as a GTPase-activating protein for RAB7, and also acts as a linker between RAB7 and RAC1, which leads to RAB7A inactivation and inhibition of E-cadherin degradation. Existing as six alternatively spliced isoforms, the gene encoding TBC1D2 maps to human chromosome 9q22.33.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TBC1D2 polyclonal antibody detects endogenous levels of TBC1D2 protein.

Bioworld Molecular Weight: ~ 105 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of TBC1D2 polyclonal antibody at 1:500 dilution
Lane 1: MCF-7 whole cell lysate
Lane 2: sp2/0 whole cell lysate
Lane 3: PC12 whole cell lysate

Immunogen: A synthetic peptide corresponding to residues in Human TBC1D2.

Conjugate: Unconjugated

Modification: Unmodified