TCF7L2 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS91324-50, BS91324-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q9NQB0(Human) Q924A0(Mouse) Unigene:105849(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, ICC/IF, IHC, IP, , FC
All Applications: WB:1:500-1:1,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100
Background: T cell factors (TCFs) comprise a family of DNA-binding transcriptional activators that are essential for lymphoid cell development. These transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. TCF-4 mainly localizes in the cytoplasm and is transported into the nucleus directly bound to β-catenin in a cooperative manner. This TCF-4/β-catenin complex induces expression of Wnt target genes, including multiple cancer-associated genes. c-Jun also interacts with TCF-4 and β-catenin, and the phosphorylation-dependent interaction between c-Jun and TCF4 regulates intestinal tumorigenesis by integrating JNK and APC/β-catenin. TCF-4 is also implicated in bipolar affective disorder.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: TCF7L2 polyclonal antibody detects endogenous levels of TCF7L2 protein.
Bioworld Molecular Weight: 68 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of TCF7L2 on Jurkat cells lysates using anti-TCF7L2 antibody at 1/1,000 dilution., ICC staining TCF7L2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Alternative Name: T-cell factor 4, TCF-4, hTCF-4, TCF7L2, HMG box transcription factor 4, hTCF 4, hTCF-4, T cell factor 4, T cell specific HMG box, T cell specific transcription factor 4, T-cell factor 4, T-cell-specific transcription factor 4, TCF 4, TCF-4, TCF4, TCF7L2, TCF7L2 protein, TF7L2, Transcription factor 7 like 2, Transcription factor 7 like 2 T cell specific HMG box, Transcription factor 7-like 2,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified