TCL1A Monoclonal Antibody - BT-MCA3865

TCL1A Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA3865-50, BT-MCA3865-100

Citations, Manuals and MSDS Available upon request.

Background: Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).

Research Areas: Epigenetics and nuclear signaling, Cancer

Target Protein: TCL1A

Applications: FCM

Reactivity: Human

Clonality: Monoclonal

Clone ID: 2E3A5

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: TCL1A

Immunogen: Purified recombinant fragment of human TCL1A (AA: 10-104) expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Purified antibody in PBS with 0.05% sodium azide.

Molecular Weight (Da): 13.5kDa

UniProt Accession: P56279

Synonyms: TCL1

GeneID: 8115

Research Use Only