TDG Polyclonal Antibody - BT-AP08909

TDG Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP08909-20, BT-AP08909-50, BT-AP08909-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by TDG (thymine DNA glycosylase) belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. TDG may have a pseudogene in the p arm of chromosome 12.

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: TDG

Applications: WB, IHC-p, IF, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: TDG Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 46053

UniProt Accession: Human: Q13569; Mouse: P56581

Synonyms: TDG; G/T mismatch-specific thymine DNA glycosylase; Thymine-DNA glycosylase

GeneID: Human: 6996

Research Use Only