Product Description

TERT Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: LM1562-50, LM1562-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellμlar senescence, as it is normally repressed in postnatal somatic cells resμlting in progressive shortening of telomeres. Deregμlation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified, the fμll-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regμlation of telomerase activity.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, IHC, ICC, FC

Alternate Names: Telomerase reverse transcriptase, HEST2, Telomerase catalytic subunit, Telomerase-associated protein 2, TP2, TERT, EST2, TCS1, TRT

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Purified recombinant fragment of human TERT (AA: 1029-1132) expressed in E. Coli.

Dilution: WB: 1:500 - 1:2000
IHC/ICC: 1:50 - 1:200
FCM: 1/200 - 1/400

Purification: Purified antibody in PBS with 0.05% sodium azide

Specificity: TERT monoclonal antibody detects endogenous levels of TERT protein.

Molecular Weight: ~ 127 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O14746

Product: Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only