Product Description

TFCP2L1 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-90356-60, E-AB-90356-120, E-AB-90356-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: TFCP2L1

Target Synonym: TFCP2L1; CRTR1; LBP-9; LBP9

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human

Application: WB

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q9NZI6

Background: Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs. With KLF2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/STAT3 and Wnt/beta-catenin signaling (By similarity. Required for normal duct development in the salivary gland and kidney (By similarity. Coordinates the development of the kidney collecting ducts intercalated (IC and principal (PC cells, which regulate acid-base and salt-water homeostasis, respectively (By similarity. Regulates the expression of IC genes including subunits B1 and D2 of the V-ATPase complex, OXGR1, CA12, SLC4A1, AQP6 and IC-specific transcription factor FOXI1 (By similarity. Regulates also the expression of JAG1 and subsequent notch signaling in the collecting duct (By similarity. JAG1 initiates notch signaling in PCs but inhibits notch signaling in ICs (By similarity. Acts as a transcriptional suppressor that may suppress UBP1-mediated transcriptional activation (By similarity. Modulates the placental expression of CYP11A1.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human TFCP2L1

Buffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000

Calculated MW: 54kDa

Observed MW: 58kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only