Product Description

TfR1/CD71 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91333-50, BS91333-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P02786(Human) Q62351(Mouse) Q99376(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC, IP, , FC

All Applications: WB:1:1,000-1:2,000
FC:1:50-1:100
IHC:1:50-1:200

Background: CD71, also known as the transferrin receptor (TFR), is a type II membrane glycoprotein that exists as a disulfide-linked homodimer of two identical subunits. CD71 binds to two molecules of transferrin and a serum iron-transport protein, and directs the cellular uptake of iron via receptor-mediated endocytosis. CD71 is expressed, typically at high levels, on all proliferating cells, reticulocytes and erythroid precursors. It is not expressed on resting leukocytes, but is upregulated upon activation of lymphocytes, monocytes and macrophages. CD71 is also found on most dividing cells and on brain endothelium. A second transferrin receptor, TFR2, also mediates the uptake of transferrin-bound iron. TFR2 is a two-subunit homodimer and is highly expressed in liver as well as in hepatocytes and erythroid precursors. Mutations in the TFR2 gene result in hereditary hemochromatosis type III (HFE3), an iron overloading disorder predominant in Caucasians.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: TfR1/CD71 polyclonal antibody detects endogenous levels of TfR1/CD71 protein.

Bioworld Molecular Weight: 85 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Transferrin Receptor on mouse placenta lysates using anti-Transferrin Receptor antibody at 1/1,000 dilution., Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-Transferrin Receptor antibody. Counter stained with hematoxylin.

Alternative Name: TR, TfR, TfR1, Trfr, TFRC, CD 71, CD71, CD71 antigen, IMD46, OTTHUMP00000208523, OTTHUMP00000208524, OTTHUMP00000208525, p90, sTfR, T9, TFR 1, TfR, TfR1, TFR1, TFRC, TR, Transferrin receptor (p90 CD71), Transferrin receptor protein 1, serum form, Trfr,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified