TGase2/TGM2 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS91335-50, BS91335-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P21980(Human) P21981(Mouse)
Host: Rabbit
Reactivity: Human, Mouse
Applications: WB, IHC, IP,
All Applications: WB:1:500-1:2,000
IHC:1:50-1:200
Background: Terminally differentiating mammalian epidermal cells acquire an insoluble, 10 to 20 nm thick protein deposit on the intracellular surface of the plasma membrane known as the cross-linked cell envelope (CE). The CE is a component of the epidermis that is generated through formation of disulfide bonds and g-glutamyl-lysine isodipeptide bonds, which are formed by the action of transglutaminases (TGases). TGases are intercellularly localizing, Ca2+-dependent enzymes that catalyze the formation of isopeptide bonds by transferring an amine on to glutaminyl residues, thereby cross-linking glutamine residues and lysine residues in substrate proteins. TGases influence numerous biological processes, including blood coagulation, epidermal differentiation, seminal fluid coagulation, fertilization, cell differentiation and apoptosis. Human keratinocyte transglutaminase (TGase1) is a membrane associated, 817 amino acid protein. Human tissue transglutaminase (TGase2) is an endothelial cell specific, 687 amino acid protein.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: TGase2/TGM2 polyclonal antibody detects endogenous levels of TGase2/TGM2 protein.
Bioworld Molecular Weight: 77 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of Transglutaminase 2 on mouse placenta (1) and lung tissue lysates using anti-Transglutaminase 2 antibody at 1/500 dilution., Western blot analysis of Transglutaminase 2 on HUVEC cell lysates using anti-Transglutaminase 2 antibody at 1/500 dilution.
Alternative Name: TG(C), TGC, TGase C, TGase H, TGase-2, TGM2, ALPHA SUBUNIT, C polypeptide, EC 2.3.2.13 antibodyepididymis secretory protein Li 45, G alpha h, G[a]h, Gh CLASS G ALPHA h, GNAH, GNAH G PROTEIN, H POLYPEPTIDE, HEL-S-45, Protein glutamine gamma glutamyltransferase 2, Protein-glutamine gamma-glutamyltransferase 2, TG 2, TG(C), TG2, TGase C, TGase H, TGase-2, TgaseII, TGC, TGC GUANINE NUCLEOTIDE BINDING PROTEIN, TGM2, TGM2, Tissue transglutaminase, Transglutaminase 2, Transglutaminase 2 C polypeptide, Transglutaminase C, Transglutaminase H, Transglutaminase-2, tTG, tTGas,
Immunogen: Recombinant protein
Conjugate: Unconjugated
Modification: Unmodified