Product Description

TGF β3 (G292) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1363-50, BS1363-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Transforming growth factor betas (TGFβs) were originally discovered due to their ability to promote anchorage-independent growth of rat NRK fibroblasts in the presence of TGFα. It is now realized that TGFβs mediate many cell-cell interactions that occur during embryonic develop ment. Three TGFβs have been identified in mam mals. TGFβ1, TGFβ2 and TGFβ3 are each syn thesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the mol ecμles. Biologically active TGFβ requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFβ3 protein has approx imately 80% identity to the mature region of both TGFβ1 and TGFβ2. However, the NH2 terminals or precursor regions of their molecμles share only 27% sequence identity.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC

Alternate Names: Transforming growth factor beta-3, TGF-beta-3, Latency-associated peptide, LAP, TGFB3, TGFβ3, TGF-β3

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 261-310 of Human TGF β3.

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: TGF β3 (G292) polyclonal antibody detects endogenous levels of pro-TGFβ3 (47 kDa) and Cleaved-TGFβ3 (13 kDa) protein.

Molecular Weight: ~ 50 kDa

Pathway: Tumor Angiogenesis, Contribution of Soluble Factors to EMT,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P10600

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only