Product Description

Thioredoxin 1 Monoclonal Antibody

Catalogue Numbers: MB66858-50, MB66858-100

Sizes: 50µl, 100µl

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P10599

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: Thioredoxin is a small redox protein found in many eukaryotes and prokaryotes. A pair of cysteines within a highly conserved, active site sequence can be oxidized to form a disulfide bond that is then reduced by thioredoxin reductase . Multiple forms of thioredoxin have been identified, including cytosolic thioredoxin 1 (TRX1) and mitochondrial thioredoxin 2 (TRX2). Thioredoxin participates in many cellular processes including redox signaling, response to oxidative stress, and protein reduction . A potential role of thioredoxin in human disorders such as cancer, aging, and heart disease is currently under investigation . Thioredoxin can play a key role in cancer progression, because it acts as a negative regulator of the proapoptotic kinase ASK1 . Changes in thioredoxin expression have been associated with meningococcal septic shock and acute lung injury .

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of Thioredoxin 1 protein.

Extra Notes: Western blot analysis of Thioredoxin 1 expression in SHSY5Y (A), A431 (B), Hela (C) whole cell lysates.

Bioworld Molecular Weight: ~ 12 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: TRDX; TRX; TRX1; Thioredoxin; Trx; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP

Immunogen: Recombinant fusion protein of human Thioredoxin 1. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified