Product Description

Thrombopoietin Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60467-50, BS60467-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Thrombopoietin (TPO or THPO), also known as c-Mpl ligand (c-Mpl L), is a cytokine that plays a central role in megakaryopoiesis by influencing the development and maturation of megakaryocytes and platelet production. TPO is expressed by both mature and progenitor megakaryocytes, as well as by human platelets. Human TPO cDNA encodes a 332 amino acid precursor with a 21 amino acid signal peptide which is cleaved to generate the mature protein. TPO isolated from serum ranges in molecμlar weight, which suggests that the protein is highly glycosylated. TPO exerts its biological effects through the TPO receptor, c-Mpl. Stimμlation of c-Mpl with TPO resμlts in the activation of the Janus tyrosine kinase family members, Tyk 2 and JAK2 which in turn phosphorylate Stat5 and Stat3, causing their nuclear translocation and the transcription of Stat responsive genes.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Thrombopoietin, C-mpl ligand, ML, Megakaryocyte colony-stimμlating factor, Megakaryocyte growth and development factor, Myeloproliferative leukemia virus oncogene ligand, THPO, MGDF, TPO, c-Mpl L

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human Thrombopoietin.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Thrombopoietin polyclonal antibody detects endogenous levels of Thrombopoietin protein.

Molecular Weight: ~ 41 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P40225

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only