Thyroglobulin Mouse Monoclonal Antibody (PT0653) - RA12253

Thyroglobulin Mouse Monoclonal Antibody (PT0653)

Size: 50μL, 100μL

Catalogue Numbers: RA12253-50, RA12253-100

Citations, Manuals and MSDS Available upon request.

Background: thyroglobulin (TG) Homo sapiens Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.25% sodium azide.

Storage Instructions: -20°C/1 year

Applications: IHC-p; IF (paraffin section)

Species Cross-Reactivity: Human

GeneID (Human): 7038

SWISS: P01266

Source: Mouse

Research Use Only