Product Description

TIAM2 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11693-50, MB11693-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q8IVF5

Host: Rabbit

Reactivity: Human

Applications: WB,IHC-F,IHC-P,ICC/IF

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200

Background: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by the accumulation of actin filaments along the altered plasma membrane . Activates specifically RAC1, but not CDC42 and RHOA.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of TIAM2 in K562, 293Lysates using TIAM2 antibody.

Bioworld Molecular Weight: Calculated MW: 190 kDa; Observed MW: 190 kDa

Specificity: IgG

Alternative Name: STEF; TIAM-2

Immunogen: Recombinant protein of human TIAM2

Conjugate: Unconjugated

Modification: Unmodified