Product Description

Tie-1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA30474-50, RA30474-100

Citations, Manuals and MSDS Available upon request.

Background: tyrosine kinase with immunoglobulin like and EGF like domains 1 (TIE1) Homo sapiens This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: IHC-p: 100-300.Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Alternative Names: TIE1; TIE; Tyrosine-protein kinase receptor Tie-1

Applications: WB; IHC-p; IF (paraffin section) ; ELISA

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 7075

Protein MW (KDa): 130

SWISS: P35590

Source: Rabbit

Research Use Only