Product Description

TIM-3/HAVCR2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS80266-50, BS80266-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: T cell immunoglobμlin and mucin domain-3 (TIM3), also called hepatitis A virus cellμlar receptor 2 (HAVCR2), isa transmembrane glycoprotein of the TIM family of immune regμlating molecμles and plays an important rolein the Th1-mediated immune response. TIM3 is expressed on the Th1 cells, CD8 T-cells, monocytes, anddendritic cells, but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosisof apoptotic cells and up-regμlates cross-presentation of apoptotic cell-associated antigens through interactionwith phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressivefunctions which enhance immune tolerance and inhibit anti-tumor immunity. Stimμlation of TIM3 with anagonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is alsoregarded as a potential target molecμle for immunotherapy. TIM3 and programmed cell death 1 (PD-1) as twoimportant coinhibitory regμlators of T cell responses, have been implicated with the T-cell dysfunction orexhaustion associated with chronic HBV infection including HBV-related HCC.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Tim, TIM-, Tim3, Timd, TIM-3, Timd3

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of mouse TIM-3/HAVCR2(NP_599011.2).

Dilution: WB, 1:500 - 1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Unmodification

Molecular Weight: 45-70KDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8VIM0

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only