Product Description

TIM3 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS67334-50, BS67334-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: T cell Ig- and mucin-domain-containing molecμles (TIMs) are a family of transmembrane proteins expressed by various immune cells. TIM-3 is an inhibitory molecμle that is induced following T cell activation . TIM-3 is expressed by exhausted T cells in the settings of chronic infection and cancer , and tumor-infiltrating T cells that coexpress PD-1 and TIM-3 exhibit the most severe exhausted phenotype . Tumor-infiltrating dendritic cells (DCs) also express TIM-3. TIM-3 expression on DCs was found to suppress innate immunity by reducing the immunogenicity of nucleic acids released by dying tumor cells . Research studies show that heterodimerization of TIM-3 with CEACAM-1 is critical for the inhibitory function of TIM-3, and co-blockade of TIM-3 and CEACAM-1 enhanced antitumor responses in a mouse model of colorectal cancer . In addition, blockade of TIM-3 in mouse models of autoimmunity enhanced the severity of disease . Finally, binding of Galectin-9 to TIM-3 expressed by Th1 cells induces T cell death .

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, IHC

Alternate Names: TIM3, TIMD3, Hepatitis A virus cellμlar receptor 2, HAVcr-2, T-cell immunoglobμlin and mucin domain-containing protein 3, TIMD-3, T-cell immunoglobμlin mucin receptor 3, TIM-3, T-cell membrane protein 3

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide of human TIM3

Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/200)

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Recognizes endogenous levels of TIM3 protein.

Molecular Weight: ~ 32 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8TDQ0

Product: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Research Use Only