Product Description

TIMM23 Mouse Monoclonal Antibody

Sizes: 25μl, 100μl

Catalogue Numbers: MB4025-25, MB4025-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: TIM23 is a subunit of the mitochondrial import inner membrane translocase complex. This complex mediates translocation of presequence-containing proteins into the mitochondrial matrix and inner membrane. Besides TIM23, there are mμltiple subunits in the complex, including TIM17A, TIM17B, and TIM50 (1, 2). Studies show that mutant huntingtin (mHTT), the protein causing neurodegenerative Huntington’s disease, binds to TIM23 subunit. There are less soluble matrix mitochondrial proteins imported by the TIM23 complex in cells expressing mHTT and in the brain tissues of Huntington’s disease patients when compared with controls (2). In addition, asbestos causes translocation of NOX4 to the mitochondrial matrix through direct interaction with TIM23 in lung macrophages. TIM23 increases NOX4-induced reactive oxygen species (ROS) in mitochondria and metabolic reprogramming to oxidative phosphorylation (3).

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Mouse

Applications: IHC, WB

Alternate Names: Mitochondrial import inner membrane translocase subunit Tim23； TIMM23； TIM23；9606 NCBI； Homo sapiens (Human)

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Fμll length human recombiant protein of human TIMM23 (NP_006318) produced in E.coli.

Dilution: WB 1:500~2000, IHC 1:2000

Purification: The antibody was affinity-purified from mouse ascites fluids or tissue cμlture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: IgG2b

Molecular Weight: ~ 22 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O14925

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only