TIRAP rabbit pAb - ES4645

TIRAP rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES4645-50, ES4645-100

Citations, Manuals and MSDS Available upon request.

Background: The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008],

Alternate Name: TIRAP; MAL; Toll/interleukin-1 receptor domain-containing adapter protein; TIR domain-containing adapter protein; Adaptor protein Wyatt; MyD88 adapter-like protein

Source: Rabbit

Applications: IHC; IF; WB; ELISA

Dilution: WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human TIRAP. AA range:52-101

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 114609

Human SWISS Prot NO: P58753

Subcellular Location: Cytoplasm. Cell membrane. Membrane. Colocalizes with DAB2IP at the plasma membrane.

Research Use Only