Product Description

TMEM173 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91357-50, BS91357-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q86WV6(Human)

Host: Rabbit

Reactivity: Human

Applications: WB, FC, ICC/IF

All Applications: WB:1:500-1:1,000
FC:1:50-1:100
ICC:1:10-1:50

Background: Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: TMEM173 polyclonal antibody detects endogenous levels of TMEM173 protein.

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodified

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of TMEM173 on U937 (1) and 293 (2) cell lysate using anti-TMEM173 antibody at 1/1,000 dilution., Flow cytometric analysis of THP-1 cells with TMEM173 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).