Product Description

TMPRSS15 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60752-50, BS60752-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Enterokinase, also known as enteropeptidase or serine protease 7, belongs to the peptidase S1 family and localizes to the intestinal brush border in the proximal small intestine. It exists as a heterodimer of a catalytic light chain (LC) and a non-catalytic heavy chain (HC) linked together by a disμlfide bond. Enterokinase HC plays a role in macromolecμlar substrate recognition and specificity. Duodenase is the serine protease responsible for the release and activation of Enterokinase from its inactive precursor. Active Enterokinase recognizes the target sequence, Asp-Asp-Asp-Asp-Lys, and is responsible for catalyzing the conversion of pancreatic trypsinogen to activated trypsin. Activated trypsin then further activates digestive enzymes such as chymotrypsin, carboxypeptidases, elastases and lipases, releasing them from their inactive precursors. Enterokinase is important for proper digestion of proteins. Improper functioning of Enterokinase may resμlt in congenital enteropeptidase deficiency. This recessively inherited disorder leads to severe protein malabsorption and can resμlt in low serum protein, chronic diarrhea and, in infants, a failure to thrive.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Enteropeptidase, Enterokinase, Serine protease 7, Transmembrane protease serine 15, TMPRSS15, ENTK, PRSS7

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human TMPRSS15

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: TMPRSS15 polyclonal antibody detects endogenous levels of TMPRSS15 protein.

Molecular Weight: ~ 113 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P98073

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only