Product Description

TNFα-IP8 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS5965-50, BS5965-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: TNFα-IP 8 (tumor necrosis factor, α-induced protein 8), also known as NFκB-inducible DED-containing protein (NDED), SCC-S2 or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NFκB and TNF. The induction of TNFα-IP 8 by TNF is dependent on the activation of NFκB. TNFα-IP 8 negatively mediates apoptosis and may also play a role in tumor progression. TNFα-IP 8 specifically inhibits caspase-8 activity, which resμlts in the inhibition of BID cleavage and caspase-3 activation during TNF-mediated apoptosis. TNFα-IP 8 is expressed at high levels in thymus, bone marrow, lymph node, spleen, thyroid, placenta and various tumor tissues, as well as fetal lung, liver and kidney. TNFα-IP 8 is present as three isoforms produced by alternative splicing.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IF

Alternate Names: Tumor necrosis factor alpha-induced protein 8, TNF alpha-induced protein 8, Head and neck tumor and metastasis-related protein, MDC-3.13, MDC3.13, NF-kappa-B-inducible DED-containing protein, NDED, SCC-S2, SCC S2, SCCS2, TNF-induced protein GG2-1, TNFAIP8, TNFα IP8, TNFαIP8, TNFα-IP 8

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 71-116 of Human TNFα-IP83.

Dilution: WB: 1:500~1:1000
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: TNFα-IP8 polyclonal antibody detects endogenous levels of TNFα-IP8 protein.

Molecular Weight: ~ 23 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O95379

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only