Product Description

TNF-α Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-68252-60, E-AB-68252-120, E-AB-68252-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: TNF-α

Target Synonym: TNF; DIF; TNF-alpha; TNFA; TNFSF2; TNLG1F; TNF alpha

Research Areas: Cancer, Cardiovascular, Metabolism, Immunology, Signaling transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: IHC, IF

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P01375

Background: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

Concentration: 1 mg/mL

Immunogen: Recombinant fusion protein of human TNF

Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000, IHC 1:50-1:200, IF 1:50-1:200

Calculated MW: 25kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only