Product Description

TNKS1 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA35406-50, RA35406-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: catalytic activity:NAD (+) + (ADP-D-ribosyl) (n)-acceptor = nicotinamide + (ADP-D-ribosyl) (n+1)-acceptor., function:May regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Has PARP activity and can modify TERF1, and thereby contribute to the regulation of telomere length., PTM:ADP-ribosylated (-auto)., PTM:Phosphorylated on serine residues by MAPK kinases upon insulin stimulation., similarity:Contains 1 PARP catalytic domain., similarity:Contains 1 SAM (sterile alpha motif) domain., similarity:Contains 15 ANK repeats., subcellular location:Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1., subunit:Oligomerizes and associates with TNKS2. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of telomeric TERF1 via the ANK repeats. Found in a complex with POT1; TERF1 and TINF2., tissue specificity:Ubiquitous; highest levels in testis.,

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight: 145

Protein Molecular Weight (kDa): 145

Storage: -20°C/1 year

Human Gene ID: 8658

Human SwissProt Number: O95271

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Research Use Only