Product Description

TNS3 Polyclonal Antibody

Catalogue Numbers: BS61397-50, BS61397-100

Sizes: 50µl, 100µl

Alternative Name: Tensin-3; Tensin-like SH2 domain-containing protein 1; Tumor endothelial marker 6; TNS3

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q68CZ2

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: The Tensin (Tns) family of proteins is involved in the maintenance of cellular structure by anchoring actin filaments at the focal adhesion via F-actin binding and capping activities. Tns proteins also contain a Src homology 2 (SH2) domain and have the ability to be phosphorylated, suggesting a role in signal transduction cascades. These diverse characteristics indicate that Tns proteins may be important links between the cytoskeleton and signal transduction pathways. Tns3, also known as TEM6 or TENS1, localizes to the focal adhesions of the plasma membrane. It is predominantly expressed in thyroid and placenta but can also be found in heart, liver, brain, prostate, pancreas, kidney, lung, skeletal muscle and white blood cells. Tns3 is essential for proper growth and development, as suggested by growth retardation and death in a number of Tns3-/- mice.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TNS3 polyclonal antibody detects endogenous levels of TNS3 protein.

Bioworld Molecular Weight: ~ 155 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of TNS3 polyclonal antibody at 1:500 dilution
Lane 1: H9C2 whole cell lysate(40ug)
Lane 2: NIH-3T3 whole cell lysate(40ug)
Lane 3: DLD whole cell lysate(40ug)

Immunogen: Synthetic peptide, corresponding to amino acids 535-580 of Human TNS3.

Conjugate: Unconjugated

Modification: Unmodified