Toll-Like Receptor 3 (2F10) Monoclonal Antibody-MB3091

Toll-Like Receptor 3 (2F10) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB3091-50, MB3091-100

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: O15455

Host: Mouse

Reactivity: Transfected

Applications: WB

All Applications: WB: 1/500-1/1000

Background: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Toll-Like Receptor 7 in CHO-K1Lysatesand CHO-K1 transfected by Toll-Like Receptor 3Lysates using Toll-Like Receptor 3 antibody.

Bioworld Molecular Weight: Calculated MW: 104 kDa

Specificity: IgG2b

Alternative Name: CD283; CD283 antigen; IIAE2; TLR 3; Tlr3; TLR3_HUMAN; Toll Like Receptor 3; Toll-like receptor 3.

Immunogen: Purified recombinant human Toll-Like Receptor 3 protein fragments expressed in E.coli.

Conjugate: Unconjugated

Modification: Unmodified