Product Description

Toll-Like Receptor 3 (2F10) Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB3091-50, MB3091-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecμlar patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopμlation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.

Category: Primary Antibody

Reactivity: Transfected

Host: Mouse

Applications: WB

Alternate Names: CD283, CD283 antigen, IIAE2, TLR 3, Tlr3, TLR3_HUMAN, Toll Like Receptor 3, Toll-like receptor 3.

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Purified recombinant human Toll-Like Receptor 3 protein fragments expressed in E.coli.

Dilution: WB: 1/500-1/1000

Purification: Affinity Purified

Specificity: IgG2b

Molecular Weight: Calcμlated MW: 104 kDa, Observed MW: Refer to figures

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O15455

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only