Toll-like Receptor 3 Mouse Monoclonal Antibody - RA12087

Toll-like Receptor 3 Mouse Monoclonal Antibody

Size: 50μL, 100μL

Catalogue Numbers: RA12087-50, RA12087-100

Citations, Manuals and MSDS Available upon request.

Background: toll like receptor 3 (TLR3) Homo sapiens The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Applications: WB

Species Cross-Reactivity: Transfected

GeneID (Human): 7098

SWISS: O15455

Source: Mouse

Research Use Only