TOP2A (Phospho Ser1213) Rabbit Polyclonal Antibody - RA30594

TOP2A (Phospho Ser1213) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA30594-50, RA30594-100

Citations, Manuals and MSDS Available upon request.

Background: catalytic activity:ATP-dependent breakage, passage and rejoining of double-stranded DNA.,enzyme regulation:Specifically inhibited by the intercalating agent amsacrine.,function:Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.,miscellaneous:Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.,PTM:Phosphorylation has no effect on catalytic activity.,similarity:Belongs to the type II topoisomerase family.,subcellular location:Generally located in the nucleoplasm.,subunit:Homodimer. Interacts with COPS5.,

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:1000-2000 ELISA 1:5000-20000

Alternative Names: DNA topoisomerase 2-alpha (EC 5.99.1.3;DNA topoisomerase II, alpha isozyme)

Applications: WB; ELISA

Species Cross-Reactivity: Human; Rat; Mouse

GeneID (Human): 7153

Protein MW (KDa): 174

SWISS: P11388

Source: Rabbit

Research Use Only