Topo IIβ rabbit pAb - ES7419

Topo IIβ rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES7419-50, ES7419-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also pla

Alternate Name: TOP2B; DNA topoisomerase 2-beta; DNA topoisomerase II; beta isozyme

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human TOP2B. AA range:1-50

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 183kD

Human Gene ID: 7155

Human SWISS Prot NO: Q02880

Subcellular Location: Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus.

Research Use Only