Topo IIIβ-1 rabbit pAb - ES3627

Topo IIIβ-1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES3627-50, ES3627-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013],

Alternate Name: TOP3B; TOP3B1; DNA topoisomerase 3-beta-1; DNA topoisomerase III beta-1

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human TOP3B. AA range:51-100

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 96kD

Human Gene ID: 8940

Human SWISS Prot NO: O95985

Subcellular Location: condensed chromosome, nucleus, cytosol,

Research Use Only