Topoisomerase IIAlpha (Phospho-Ser1469) Rabbit Polyclonal Antibody - BT-AP13126

Topoisomerase IIAlpha (Phospho-Ser1469) Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP13126-20, BT-AP13126-50, BT-AP13126-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a DNA topoisomerase| an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation| chromatid separation| and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another| thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form| alpha| is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also pla

Research Areas: Epigenetics and nuclear signaling; Cancer

Target Protein: TOP2A

Applications: WB

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Topoisomerase IIalpha

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P11388; Mouse: Q01320; Rat: P41516

Synonyms: Topoisomerase IIα;Ser1469; DNA topoisomerase 2-alpha; EC 5.99.1.3; DNA topoisomerase II; alpha isozyme

GeneID: Human: 7153; Mouse: 21973; Rat: 360243

Research Use Only