TORC1 Monoclonal Antibody-MB0169

TORC1 Monoclonal Antibody

Product: Mouse IgM, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Sizes: 50µl, 100µl

Catalogue Numbers: MB0169-50, MB0169-100

Swiss-Prot: Q6UUV9

Host: Mouse IgM

TORC1 Monoclonal Antibody-MB0169

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Reactivity: Human, Mouse, Rat, Monkey

Applications: WB,

All Applications: WB: 1:1000~2000

Background: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites.Acts as a coactivator, in the SIK/TORC signaling pathway,being active when dephosphorylated and acts independently of CREB1 ´Ser-133´ phosphorylation.Enhances the interaction of CREB1 with TAF4.Regulates the expression of specific CREB-activated genes such as the steroidogenic gene,StAR.Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells.Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses.May be required for dendritic growth of developing cortical neurons.

Purification and Purity: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: This antibody detects endogenous levels of TORC1 and does not cross-react with related proteins

Bioworld Molecular Weight: Predicted band size:78KDa
Observed band size:78KDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blotDetection of TORC1 mAb in Hela, mouse brain, SW480, COS7, C6 and 3T3 cellLysates using TORC1 mAb (1:2000 diluted) ., Western blot (WB) analysis of TORC1 mAb at 1:5000 dillution
Lane 1: HeLa whole cell lysate (30μg)
Lane 2: NIH-3T3 whole cell lysate (30μg)
Lane 3: The Brain tissue lysate of Rat (30μg)
Lane 4: H9C2 whole cell lysate (40μg)

Alternative Name: KIAA0616; CREB regulated transcription coactivator 1; CREB-regulated transcription coactivator 1; CRTC1; CRTC1; FLJ14027; KIAA0616; MECT 1; Mucoepidermoid carcinoma translocated 1; Mucoepidermoid carcinoma translocated protein 1; TORC-1; TORC1; Transducer of CREB protein 1; Transducer of regulated cAMP response element binding protein 1; Transducer of regulated cAMP response element-binding protein (CREB) 1; Transducer of regulated cAMP response element-binding protein 1; WAMTP1; MECT1; TORC1; TORC-1; WAMTP1.

Immunogen: Recombinant full length Human TORC1.

Modification: Unmodified

Conjugate: Unconjugated