TORC1 (N-terminus) Monoclonal Antibody-MB0104

TORC1 (N-terminus) Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB0104-50, MB0104-100

Product: Mouse IgM, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q6UUV9

Host: Mouse IgG2b

Reactivity: Human

Applications: WB, FC, ICC, IP,

All Applications: WB: 1:1000
ICC: 1:100~300
IP: 1:50~200
FC: 1:50~100

Background: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 ´Ser-133´ phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses (By similarity)

Purification and Purity: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This antibody detects endogenous levels of TORC1 and does not cross-react with related proteins

Bioworld Molecular Weight: Predicted band size: 69KDa
Observed band size: 69KDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot detection of TORC1 (N-terminus) antibody in Hela and Jurkat lysates using TORC1 (N-terminus) antibody (1:1000 diluted)., Flow Cytometry analysis of K562 cells stained with TORC1(N-terminus) (red, 1/100 dilution), followed by FITC-conjugated goat anti-mouse IgG. Blue line histogram represents the isotype control, normal mouse IgG., Immunocytochemistry stain of Hela using TORC1 antibody (1:300)., Immunoprecipitation analysis of Hela cell lysate using CRTC1 antibody.

Alternative Name: KIAA0616; CREB regulated transcription coactivator 1; CREB-regulated transcription coactivator 1; CRTC1; CRTC1; FLJ14027; KIAA0616; MECT 1; Mucoepidermoid carcinoma translocated 1; Mucoepidermoid carcinoma translocated protein 1; TORC-1; TORC1; Transducer of CREB protein 1; Transducer of regulated cAMP response element binding protein 1; Transducer of regulated cAMP response element-binding protein (CREB) 1; Transducer of regulated cAMP response element-binding protein 1; WAMTP1; MECT1; TORC1; WAMTP1

Immunogen: Synthetic peptide, corresponding to the N-terminus of Human TORC1.

Conjugate: Unconjugated

Modification: Unmodified