Product Description

TorsinA Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66712-50, MB66712-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regμlation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellμlar trafficking and may regμlate the subcellμlar location of mμltipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modμlation of dopamine neurotransmission. In the endoplasmic reticμlum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: DQ2, DYT1, TORA, Torsin-1A, Dystonia 1 protein, Torsin ATPase 1, Torsin family 1 member A

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fusion protein of human TorsinA. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/4000)

Specificity: Recognizes endogenous levels of TorsinA protein.

Molecular Weight: ~ 35 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O14656

Product: Mouse IgG1. Supplied in crude ascites with 0.01% sodium azide.

Research Use Only