TP53INP2 Polyclonal Antibody
Catalogue Numbers: BS61399-50, BS61399-100
Sizes: 50µl, 100µl
Alternative Name: Tumor protein p53-inducible nuclear protein 2; Diabetes and obesity-regulated gene; p53-inducible protein U; PIG-U; TP53INP2
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q8IXH6
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB
All Applications: WB: 1:500~1:1000
Background: TP53INP2 (tumor protein p53 inducible nuclear protein 2), also known as DOR or PINH, is a 220 amino acid nuclear protein that is expressed in developing murine brain and spinal cord, as well as in the sensory and motor neuron tracts of the peripheral nervous system. A novel protein involved in the autophagy of mammalian cells, TP53INP2 translocates from the nucleus to the autophagosome structures after activation of autophagy by rapamycin or starvation. Necessary for autophagosome development and considered a scaffold protein, TP53INP2 recruits LC3 and/or LC3-related proteins, such as GABARAP and GABARAP-like2, to the autophagosome membrane by interacting with the transmembrane protein TMEM49. The gene encoding TP53INP2 is located on human chromosome 20, which is comprised of approximately 2% of the human genome and contains nearly 63 million bases that encode over 600 genes.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: TP53INP2 polyclonal antibody detects endogenous levels of TP53INP2 protein.
Bioworld Molecular Weight: ~ 23 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of TP53INP2 polyclonal antibody at 1:500 dilution
Lane 1: PC12 whole cell lysate(40ug)
Lane 2: NIH-3T3 whole cell lysate(40ug)
Lane 3: HEK293T whole cell lysate(40ug)
Lane 4: RAW264.7 whole cell lysate(40ug)
Immunogen: Synthetic peptide, corresponding to amino acids 148-193 of Human TP53INP2.
Conjugate: Unconjugated
Modification: Unmodified