tPA Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS91369-50, BS91369-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P00750(Human) P11214(Mouse) P19637(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, IHC
All Applications: WB:1:500-1:1,000
IHC:1:50-1:200
Background: uPA (urokinase-type plasminogen activator) and tPA (tissue plasminogen activator), which are serine proteases and members of the trypsin family, are essential to the intrinsic coagulation system. tPA is primarily involved in fibrinolysis, whereas uPA principally mediates cell migration and tissue remodeling processes. uPA and tPA are responsible for cleaving plasminogen, a large serum β-globulin that is deposited on the Fibrin strands within a thrombus. uPA and tPA preferentially target plasminogen at the Arg-Val bond to produce plasmin (also designated fibrinolysin), which is a trypsin-like enzyme that acts on Arg-Lys bonds in Fibrin and Fibrinogen and contributes to the systematic activation of the coagulation cascade. uPA and tPA each consist of two chains that are designated A and B. The A chain of uPA can be cleaved, resulting in low and high molecular mass forms. uPA and tPA are regulated by the serpin family members PAI-1 and PAI-2, which are serine proteinase inhibitors that complex with uPA, tPA and other targeted proteinases and then slowly disassociate to produce cleaved species that fold into stable inactive conformations.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: tPA polyclonal antibody detects endogenous levels of tPA protein.
Bioworld Molecular Weight: 63 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-PLAT antibody. Counter stained with hematoxylin., Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-PLAT antibody. Counter stained with hematoxylin.
Alternative Name: t-PA, t-plasminogen activator, tPA, PLAT, Alteplase, DKFZp686I03148, Plasminogen activator tissue, Plasminogen activator tissue type, PLAT, Reteplase, t PA, T Plasminogen Activator, t-PA, T-plasminogen activator, Tissue plasminogen activator (t PA), Tissue type plasminogen activator, Tissue-type plasminogen activator chain B, tPA, TPA, TPA1,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified