tPA Polyclonal Antibody - RA35454

tPA Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA35454-50, RA35454-100

Citations, Manuals and MSDS Available upon request.

Background: plasminogen activator, tissue type (PLAT) Homo sapiens This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Alternative Names: PLAT; Tissue-type plasminogen activator; t-PA; t-plasminogen activator; tPA; Alteplase; Reteplase

Applications: WB; ELISA

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 5327

Protein MW (KDa): 63

SWISS: P00750

Source: Rabbit

Research Use Only