TPD52L1 Polyclonal Antibody-BS8203

TPD52L1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS8203-50, BS8203-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q16890

Host: Rabbit

Reactivity: Human

Applications: IF

All Applications: IF 1:20 - 1:50

Background: The cell commits to dividing during the G2/M phase transition, and the timing of mitotic entry is tightly regulated to guarantee correct chromosome segregation. D53, also referred to as tumor protein D52-like 1 (TPD52L1), is a coiled-coil motif-bearing member of the D52 tumor protein family. D53 intereacts with 14-3-3, a negative regulator of the G2/M transition, in breast cancer cells. Expression of D53 is highly upregulated at the G2/M phase transition in breast cancer cell lines, and deregulated expression of this protein can adversely affect the completion of mitosis. D53 may function as a signaling intermediate and/or regulator of vesicle trafficking and cell proliferation.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TPD52L1 polyclonal antibody detects endogenous levels of TPD52L1 protein.

Bioworld Molecular Weight: ~ 22 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunofluorescence analysis of U2OS cell using TPD52L1 antibody. Blue: DAPI for nuclear staining.

Alternative Name: Tumor protein D53; hD53; Tumor protein D52-like 1; TPD52L1

Immunogen: Recombinant full length Human TPD52L1.

Conjugate: Unconjugated

Modification: Unmodified